CEPAC and comparative effectiveness research.
نویسنده
چکیده
منابع مشابه
Markov Modeling of Hiv Infection In Russian Population.
Over the past five years, the prevalence and incidence of HIV in Russian Federation have increased dramatically (Fig. 1-2) [1-6]. The application of global Markov models, i.e. ARAMIS and CEPAC, for cost-effectiveness analysis in Russia is not possible due to differences in the disease classifications and lack of statistical data. The purpose of this work was the modeling of HIV progression in R...
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The CEPAC model incorporates modified intention-totreat estimates for viral suppression. In intention-to-treat estimates, deaths, losses to follow-up, and lack of 24-week HIV RNA data are defined as virologic failures; discontinuations of therapy due to toxicity are analyzed separately. As-treated antiretroviral therapy efficacies from the OCTANE trial were very similar to the intention-totreat...
متن کاملUsing Observational Data to Calibrate Simulation Models.
BACKGROUND Individual-level simulation models are valuable tools for comparing the impact of clinical or public health interventions on population health and cost outcomes over time. However, a key challenge is ensuring that outcome estimates correctly reflect real-world impacts. Calibration to targets obtained from randomized trials may be insufficient if trials do not exist for populations, t...
متن کاملCost-effectiveness of CYP2B6 genotyping to optimize efavirenz dosing in HIV clinical practice.
AIMS To assess the cost-effectiveness of CYP2B6 genotyping to guide efavirenz dosing for initial HIV therapy in the USA. METHODS We used the Cost-Effectiveness of Preventing AIDS Complications (CEPAC) microsimulation model to project quality-adjusted life expectancy and lifetime costs (2014 US dollars) for efavirenz-based HIV therapy with or without CYP2B6 genotyping. We assumed that with gen...
متن کاملComparative effectiveness research in the United States: a catalyst for innovation.
Recent calls for value in the US healthcare system have spurred an increase in comparative effectiveness research, which generates evidence on competing treatment options to inform healthcare stakeholders. As a large healthcare purchaser, the federal government has made several significant investments in comparative effectiveness research. Notably, in 2009 the American Recovery and Reinvestment...
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عنوان ژورنال:
- Connecticut medicine
دوره 76 4 شماره
صفحات -
تاریخ انتشار 2012